File(s) under permanent embargo
A systematic review and meta-analysis of prospective transition from major depression to bipolar disorder
journal contribution
posted on 2017-04-01, 00:00 authored by A Ratheesh, C Davey, S Hetrick, M Alvarez-Jimenez, C Voutier, A Bechdolf, P D McGorry, J Scott, Michael BerkMichael Berk, S M CottonSome people with major depressive disorder (MDD) may be at a pre-onset stage for bipolar disorder (BD), where early identification or prevention efforts may be feasible. We aimed to identify rates and characteristics predictive of transition to BD in prospective follow-up studies of people with MDD. Using a systematic search strategy, we identified studies with a diagnostic ascertainment of MDD and BD of an adequate standard, and where the minimum length of follow-up was 6 months. We examined the incidence and point prevalence of BD and the pooled odds ratios (OR) for baseline predictors. From 5554 unique publications, 56 were included. Nearly a quarter of adults (22.5%) and adolescents with MDD followed up for a mean length of 12-18 years developed BD, with the greatest risk of transition being in the first 5 years. The meta-analysis identified that transition from MDD to BD was predicted by family history of BD (OR = 2.89, 95% CI: 2.01-4.14, N = 7), earlier age of onset of depression (g = -0.33, SE = 0.05, N = 6) and presence of psychotic symptoms (OR = 4.76, 95% CI: 1.79-12.66, N = 5). Participants with the identified risk factors merit closer observation and may benefit from prevention efforts, especially if outcomes broader than BD are considered.
History
Journal
Acta psychiatrica ScandinavicaVolume
135Issue
4Pagination
273 - 284Publisher
Wiley-BlackwellLocation
London, Eng.Publisher DOI
ISSN
0001-690XeISSN
1600-0447Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, John Wiley & Sons A/S.Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC