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Acute delirium in the setting of primary hypothyroidism: the role of thyroid hormone replacement therapy.

Version 2 2024-05-30, 15:26
Version 1 2015-03-18, 10:58
journal contribution
posted on 2024-05-30, 15:26 authored by S El-Kaissi, MA Kotowicz, Michael BerkMichael Berk, JR Wall
Psychiatric illness, mostly mania and psychosis, are reported to occur after rapid normalization of thyroid function in patients with primary hypothyroidism. It is generally believed that the gradual restoration of thyroid function may reduce the risk of psychiatric complications. This case report describes the occurrence of acute delirium in a 67-year-old man with primary hypothyroidism shortly after the initiation of thyroid hormone replacement. The use of low-dose thyroxine initially and persistent severe biochemical hypothyroidism on presentation with psychiatric symptoms illustrate that psychiatric illness can still occur despite unaggressive thyroid hormone replacement. A temporal relationship with the initiation of thyroxine and rapid recovery of mental state over 1 to 2 weeks differentiate this condition from hypothyroidism-related psychopathology, which tends to have a more prolonged course.

History

Journal

Thyroid

Volume

15

Pagination

1099-1101

Location

United States

ISSN

1050-7256

eISSN

1557-9077

Language

eng

Publication classification

C3.1 Non-refereed articles in a professional journal

Copyright notice

2005, Mary Ann Liebert

Issue

9

Publisher

Mary Ann Liebert