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Acute ethanol exposure in pregnancy alters the insulin-like growth factor axis of fetal and maternal sheep
journal contribution
posted on 2007-02-01, 00:00 authored by Kathryn L Gatford, Penelope A Dalitz, Megan L Cock, Richard Harding, Julie OwensJulie OwensMaternal ethanol intake during pregnancy impairs fetal growth, but mechanisms are not clearly defined. Reduced IGF abundance or bioavailability in the fetus and/or mother may contribute to this growth restriction. We hypothesized that an episode of acute ethanol exposure, mimicking binge drinking would restrict fetal growth and perturb the maternal and fetal IGF axes. Pregnant sheep were infused intravenously with saline or ethanol (1 g/kg maternal wt) over 1 h, on days 116, 117, and 118 of gestation (start of 1st infusion = time 0, term is 147 days). Maternal and fetal plasma IGF and IGF-binding protein (IGFBP) concentrations were measured before and after each infusion. Compared with controls, ethanol exposure reduced fetal weight at day 120 by 19%, transiently reduced maternal plasma IGF-I (-35%) at 30 h, and decreased fetal plasma IGF-II (-28%) from 24 to 54 h after the first infusion. Ethanol exposure did not alter maternal or fetal plasma concentrations of IGFBP-2 and IGFBP-3, measured by Western ligand blotting. We conclude that suppression of maternal and fetal IGF abundance may contribute to fetal growth restriction induced by acute or binge ethanol exposure.
History
Journal
American journal of physiology: endocrinology and metabolismVolume
292Issue
2Pagination
E494 - E500Publisher
American physiological societyLocation
Bethesda, Md.Publisher DOI
ISSN
0193-1849Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2007, American Physiological SocietyUsage metrics
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No categories selectedKeywords
AnimalsEthanolFemaleFetal BloodFetal Growth RetardationFetal WeightInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IInsulin-Like Growth Factor IIMaternal-Fetal ExchangePregnancyPregnancy, AnimalSheepSomatomedinsScience & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismPhysiologyalcoholgestationfetal growth restrictioninsulin-like growth factorbinding proteinFACTOR-BINDING-PROTEINSPRENATAL ALCOHOL EXPOSUREIGF GENE-EXPRESSIONFACTOR-ICIRCULATING LEVELSSOMATOTROPIC AXISPOSTNATAL-GROWTHGLUCOSE-UPTAKEMESSENGER-RNARATS
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