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Acute phase proteins in major depression
journal contributionposted on 1997-11-01, 00:00 authored by Michael BerkMichael Berk, A A Wadee, R H Kuschke, A O'Neill-Kerr
Extensive evidence exists associating depression with changes in the immune system. The present study evaluates the levels of complement components C3 and C4, C-reactive proteins, and IL-6 in patients who met DSM-III-R diagnostic criteria for major depressive disorder, as well as controls. Whereas no significant differences between the mean levels of C3 could be detected between depressed patients and controls, the levels of C4, IL-6 (where detected), and C-reactive protein were significantly raised in the group with a depressive disorder. Our study suggests an interaction between psychological state and immune systems operative in host defenses.
JournalJournal of psychosomatic research
Pagination529 - 534
LocationAmsterdam, The Netherlands
Publication classificationC1.1 Refereed article in a scholarly journal
Copyright notice1997, Elsevier Science Inc.
Acute-Phase ProteinsAdultC-Reactive ProteinComplement C3Complement C4Depressive Disorder, MajorFemaleHumansInterleukin-6MaleMiddle AgedPsychiatric Status Rating ScalesPsychoneuroimmunologyReference ValuesScience & TechnologyLife Sciences & BiomedicinePsychiatryacute phase proteinsdepression IL-6SOLUBLE INTERLEUKIN-2 RECEPTORMYCOBACTERIAL FRACTIONSLYMPHOCYTE FUNCTIONCYTOKINE PRODUCTIONNEUTROPHILILLNESSIMMUNOCOMPETENCEPHAGOCYTOSISDISTURBANCESSUPERNATANTS