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Acute tolerance to alcohol: changes in subjective effects among social drinkers

journal contribution
posted on 1989-03-01, 00:00 authored by I Portans, J M White, Petra StaigerPetra Staiger
The development of acute of acute tolerance to the subjective effects of alcohol was examined in 32 social drinkers. Measures were made of self-reported level of intoxication and responses to questions from the alcohol scale of the Addiction Research Centre Inventory. The time to peak self-reported intoxication level was found to be 20 min earlier than the time to peak blood alcohol concentration. Changes from the ascending to the descending limb of the blood alcohol curve were found with five of the ARCI questions. In all cases the proportion of alcohol-typical responses was lower on the descending portion of the curve. even though blood alcohol levels were equivalent. Further analyses examined the effects of prior drinking history on the development of acute tolerance. Peak self-reported intoxication levels were significantly lower and occurred earlier for heavier drinkers. Furthermore, for four of the five ARCI questions heavier drinkers were less likely to give analcohol-typical response than lighter drinkers on the ascending portion of the curve.

History

Journal

Psychopharmacology

Volume

97

Issue

3

Pagination

365 - 369

Publisher

Springer

Location

Berlin, Germany

ISSN

0033-3158

eISSN

1432-2072

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1989, Springer-Verlag