dwyer-adenosinegeneration-2007.pdf (1.43 MB)
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
journal contribution
posted on 2007-06-01, 00:00 authored by S Deaglio, Karen DwyerKaren Dwyer, W Gao, D Friedman, A Usheva, A Erat, J F Chen, K Enjyoji, J Linden, M Oukka, V K Kuchroo, T B Strom, S C RobsonThe study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression. We show that the expression of CD39/ENTPD1 in concert with CD73/ecto-5′-nucleotidase distinguishes CD4+/CD25+/ Foxp3+ T reg cells from other T cells. These ectoenzymes generate pericellular adenosine from extracellular nucleotides. The coordinated expression of CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops, indicating roles in the inhibitory function of T reg cells. Consequently, T reg cells from Cd39-null mice show impaired suppressive properties in vitro and fail to block allograft rejection in vivo. We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation. JEM © The Rockefeller University Press.
History
Journal
Journal of experimental medicineVolume
204Issue
6Pagination
1257 - 1265Publisher
Rockefeller University PressLocation
Birmingham, Ala.Publisher DOI
Link to full text
ISSN
0022-1007eISSN
0022-1007Language
engPublication classification
C1.1 Refereed article in a scholarly journalUsage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC