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Adult height and cancer mortality in Asia: The Asia Pacific Cohort Studies Collaboration

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journal contribution
posted on 01.03.2010, 00:00 authored by G D Batty, F Barzi, M Woodward, K Jamrozik, J Woo, H C Kim, H Ueshima, Rachel HuxleyRachel Huxley, Asia Pacific Cohort Studies Collaboration
Background: The observation that taller people experience an increased risk of selected cancers is largely restricted to Caucasian cohorts. These associations may plausibly differ in Asian populations. For the first time, we make direct comparison in the same analyses of the associations between height and a series of malignancies in Australasian (Caucasian) and Asian populations.
Methods: Analyses were based on the Asia Pacific Cohort Studies Collaboration of 506 648 study participants (408 381 Asia, 98 267 Australasia) drawn from 38 population-based cohort studies. Cox proportional hazards regression was used to estimate the relationship between height and cancer rates.
Results: A total of 3 272 600 person-years of follow-up gave rise to 7497 cancer deaths (4415 in Asia; 3082 in Australasia). After multiple adjustments and left censoring, taller individuals experienced increased rates of carcinoma of the intestine (men and women); all cancers, liver, lung, breast, 'other' malignancies (all women); and cancers of the prostate and bladder (men). No consistent regional (Asia versus Australasia) or sex differences were observed.
Conclusions: In the present study, taller men and women had an elevated risk of selected malignancies. These associations did not differ appreciably between Asian and Caucasian populations.

History

Journal

Annals of Oncology

Volume

21

Issue

3

Pagination

646 - 654

Publisher

Elsevier

Location

Amsterdam, Netherlands

ISSN

0923-7534

eISSN

1569-8041

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2009, The Authors and 2009, European Society for Medical Oncology