Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide
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journal contribution
posted on 2007-09-01, 00:00authored byS L Khaw, P A Downie, K D Waters, David Ashley, J A Heath
Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. We report a series of children with malignant disease, who developed such reactions following mesna administration and discuss possible mechanisms and management issues.