holloway-allcausemortality-2017.pdf (863.75 kB)
Download file

All-cause mortality risk in Australian women with impaired fasting glucose and diabetes

Download (863.75 kB)
journal contribution
posted on 01.01.2017, 00:00 authored by L L F de Abreu, Kara KewKara Kew, Mohammadreza MohebbiMohammadreza Mohebbi, Muhammad Sajjad, Mark KotowiczMark Kotowicz, Julie PascoJulie Pasco
AIMS: Impaired fasting glucose (IFG) and diabetes are increasing in prevalence worldwide and lead to serious health problems. The aim of this longitudinal study was to investigate the association between impaired fasting glucose or diabetes and mortality over a 10-year period in Australian women. METHODS: This study included 1167 women (ages 20-94 yr) enrolled in the Geelong Osteoporosis Study. Hazard ratios for all-cause mortality in diabetes, IFG, and normoglycaemia were calculated using a Cox proportional hazards model. RESULTS: Women with diabetes were older and had higher measures of adiposity, LDL cholesterol, and triglycerides compared to the IFG and normoglycaemia groups (all p < 0.001). Mortality rate was greater in women with diabetes compared to both the IFG and normoglycaemia groups (HR 1.8; 95% CI 1.3-2.7). Mortality was not different in women with IFG compared to those with normoglycaemia (HR 1.0; 95% CI 0.7-1.4). CONCLUSIONS: This study reports an association between diabetes and all-cause mortality. However, no association was detected between IFG and all-cause mortality. We also showed that mortality in Australian women with diabetes continues to be elevated and women with IFG are a valuable target for prevention of premature mortality associated with diabetes.

History

Journal

Journal of diabetes research

Volume

2017

Article number

2042980

Pagination

1 - 8

Publisher

Hindawi Publishing Corporation

Location

Cairo, Egypt

eISSN

2314-6753

Language

eng

Publication classification

C1 Refereed article in a scholarly journal; C Journal article

Copyright notice

2017, The Authors