wood-alteredcorticolthickness-2014.pdf (108.93 kB)
Altered cortical thickness following prenatal sodium valproate exposure
journal contribution
posted on 2014-07-01, 00:00 authored by Amanda WoodAmanda Wood, J Chen, S Barton, C Nadebaum, V A Anderson, C Catroppa, D C Reutens, T J O'Brien, F VajdaAnnals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.
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Annals of clinical and translational neurologyVolume
1Issue
7Pagination
497 - 501Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
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2328-9503Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2014, The AuthorsUsage metrics
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