macreadie-alzheimersabeta-2007.pdf (449.25 kB)
Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response
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posted on 2007-12-01, 00:00 authored by J Caine, S Sankovich, H Antony, L Waddington, Peter MacreadiePeter Macreadie, J Varghese, I MacreadieThe 42 amino acid Alzheimer's Aβ peptide is involved in the progression of Alzheimer's disease. Here we describe the effects of intracellular Aβ, produced through its attachment to either end of a green fluorescent protein, in yeast. Cells producing Aβ exhibited a lower growth yield and a heat shock response, showing that Aβ fusions promote stress in cells and supporting the notion that intracellular Aβ is a toxic molecule. These studies have relevance in understanding the role of Aβ in the death of neuronal cells, and indicate that yeast may be a new tractable model system for the screening for inhibitors of the stress caused by Aβ.
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FEMS yeast researchVolume
7Issue
8Pagination
1230 - 1236Publisher
Oxford University PressLocation
Oxford, Eng.Publisher DOI
ISSN
1567-1356Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2007, Oxford University PressUsage metrics
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