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Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response

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posted on 2007-12-01, 00:00 authored by J Caine, S Sankovich, H Antony, L Waddington, Peter MacreadiePeter Macreadie, J Varghese, I Macreadie
The 42 amino acid Alzheimer's Aβ peptide is involved in the progression of Alzheimer's disease. Here we describe the effects of intracellular Aβ, produced through its attachment to either end of a green fluorescent protein, in yeast. Cells producing Aβ exhibited a lower growth yield and a heat shock response, showing that Aβ fusions promote stress in cells and supporting the notion that intracellular Aβ is a toxic molecule. These studies have relevance in understanding the role of Aβ in the death of neuronal cells, and indicate that yeast may be a new tractable model system for the screening for inhibitors of the stress caused by Aβ.

History

Journal

FEMS yeast research

Volume

7

Issue

8

Pagination

1230 - 1236

Publisher

Oxford University Press

Location

Oxford, Eng.

ISSN

1567-1356

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2007, Oxford University Press

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