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An efficient solvent- and catalyst-free synthesis of bicyclic pyridones with high molecular diversity via cascade reaction
journal contributionposted on 2018-01-01, 00:00 authored by H M Fu, H B Wang, L J Yang, Wenrong YangWenrong Yang, C Huang
Two efficient cascade routes for synthesis of substituted bicyclic pyridines under solvent-and catalyst-free conditions have been developed. One is conducted by refluxing the reaction mixture of heterocyclic ketene aminals (HKAs), triethoxymethane and dicarbonyl compounds. The other one is proceeded with HKAs and diethyl ethoxymethylenemalonate (EMME) under ultrasound irradiation. Both routes for preparation of bicyclic 2-pyridones carried out with low cost and easy available substrates and achieved diversity of target compounds in good yields efficiently and environmental-friendly.
Pagination311 - 323
PublisherJapan Institute of Heterocyclic Chemistry
Publication classificationC Journal article; C1 Refereed article in a scholarly journal
Copyright notice2018, The Japan Institute of Heterocyclic Chemistry