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An enhancement of luminol chemiluminescence by cobalt hydroxide decorated porous graphene and its application in glucose analysis

journal contribution
posted on 2024-03-06, 05:33 authored by SM Beigi, F Mesgari, M Hosseini, M Aghazadeh, MR Ganjali
Here, it was shown that a cobalt hydroxide/porous-graphene nanocomposite (PG/Co(OH)2) has great catalytic capability toward luminol as a chemiluminescence active substrate. We made use of PG/Co(OH)2 for developing a super-sensitive quantitative analytical tool for glucose detection. After optimizing the effective factors, the relative chemiluminescence intensity was found to linearly change with H2O2 concentration from 5.0 × 10-11 to 1.0 × 10-6 mol L-1 (R2 = 0.99023) and a detection limit as low as 8.0 × 10-12 mol L-1 (S/N = 3). The association between the CL signal intensity and H2O2 concentration was obtained. Based on the production of H2O2 by glucose oxidase from glucose, the detection of glucose was performed and it could be linearly detected in the range from 3.0 × 10-9 to 4.0 × 10-5 mol L-1 (R2 = 0.99106) with a detection limit of 6.4 × 10-10 mol L-1. This method was also implemented for non-invasive determination of glucose in tears and saliva, which is important for diabetic patients with frequent/continuous glucose monitoring requirements, and satisfactory results were obtained.

History

Journal

Analytical Methods

Volume

11

Pagination

1346-1352

Location

Cambridge, Eng.

ISSN

1759-9660

eISSN

1759-9679

Language

English

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

10

Publisher

ROYAL SOC CHEMISTRY