We evaluated gender-based and cross-cultural equivalence of the Body Dissatisfaction Scale of the Body Change Inventory in a sample of 4,005 adolescents from 7 cultures that represent diverse body image ideals and response styles. Results of multigroup confirmatory factor analyses demonstrated equivalence of the scale across gender but not across cultures. Follow-up analyses identified small but significant cross-cultural differences in response styles (specifically, acquiescence and middle response option endorsement) as the source of this noninvariance. We recommend use of this scale for gender-based comparisons but caution that researchers should evaluate the presence of response biases before making substantive conclusions about cross-cultural differences in body dissatisfaction.