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Anti-Angiogenic Properties of Ginsenoside Rg3
journal contribution
posted on 2020-01-01, 00:00 authored by Maryam Nakhjavani, E Smith, A R Townsend, T J Price, J E HardinghamGinsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3). Rg3 is an intriguing molecule due to its anti-cancer properties. One facet of the anti-cancer properties of Rg3 is the anti-angiogenic action. This review describes the controversies on the effects and effective dose range of Rg3, summarizes the evidence on the efficacy of Rg3 on angiogenesis, and raises the possibility that Rg3 is a prodrug
History
Journal
MoleculesVolume
25Issue
21Article number
4905Pagination
1 - 18Publisher
MDPILocation
Basel, SwitzerlandPublisher DOI
Link to full text
ISSN
1420-3049eISSN
1420-3049Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Keywords
20(R)-ginsenoside Rg320(S)-ginsenoside Rg3angiogenesisBiochemistry & Molecular BiologyChemistryChemistry, MultidisciplinaryCOLLAGEN-SYNTHESISENDOTHELIAL GROWTH-FACTORepimerginsenoside Rg3HEPATOCELLULAR-CARCINOMAINHIBITS ANGIOGENESISIONIZATION MASS-SPECTROMETRYLife Sciences & BiomedicineNITRIC-OXIDE SYNTHASEPANAX-GINSENGPhysical SciencesPROSTATE-CANCERScience & TechnologyOrganic Chemistry
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