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Antifungal synergy of theaflavin and epicatechin combinations against Candida albicans

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journal contribution
posted on 2013-01-01, 00:00 authored by J Betts, D Wareham, Stephen Haswell, S Kelly
New antifungal agents are required to compensate for the increase in resistance to standard antifungal agents of Candida albicans, which is an important opportunistic fungal pathogen that causes minor infections in many individuals but very serious infections in those who are immune-compromised. In this study, combinations of theaflavin and epicatechin are investigated as potential antifungal agents and also to establish whether antifungal synergy exists between these two readily accessible and cost-effective polyphenols isolated from black and green tea. The results of disc diffusion assays showed stronger antibacterial activity of theaflavin:epicatechin combinations against C. albicans NCTC 3255 and NCTC 3179, than that of theaflavin alone. Minimum inhibitory concentrations (MICs) of 1,024 μg/ml with theaflavin and 128-256 μg/ml with theaflavin:epicatechin combinations were found. The fractional inhibitory concentration indexes were calculated, and the synergy between theaflavin and epicatechin against both isolates of C. albicans was confirmed. Theaflavin:epicatechin combinations show real potential for future use as a treatment for infections caused by C. albicans.

History

Journal

Journal of microbiology and biotechnology

Volume

23

Issue

9

Pagination

1322 - 1326

Publisher

Korean Society for Microbiology Biotechnology

Location

Seoul, Korea

ISSN

1017-7825

eISSN

1738-8872

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2013, Korean Society for Microbiology Biotechnology