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Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp

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journal contribution
posted on 1997-09-01, 00:00 authored by Colin BarrowColin Barrow, J J Oleynek, V Marinelli, H H Sun, P Kaplita, D M Sedlock, A M Gillum, C C Chadwick, R Cooper
A related group of compounds belonging to the antimycin class of antibiotics was found in culture broth produced by a Streptomyces species. The group includes known antimycins A1, A2, A3 and A4, and new antimycins A7 and A8. These compounds inhibit ATP-citrate lyase with Ki values of 4 to 60 microM against the substrate magnesium citrate. The structures of the new antimycins were determined by spectroscopic analyses.

History

Journal

Journal of antibiotics

Volume

50

Issue

9

Pagination

729 - 733

Publisher

Japan Antibiotics Research Association

Location

Tokyo, Japan

ISSN

0021-8820

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1997, Japan Antibiotics Research Association