barrow-antimycinsinhibitors-1997.pdf (300.04 kB)
Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp
journal contribution
posted on 1997-09-01, 00:00 authored by Colin BarrowColin Barrow, J J Oleynek, V Marinelli, H H Sun, P Kaplita, D M Sedlock, A M Gillum, C C Chadwick, R CooperA related group of compounds belonging to the antimycin class of antibiotics was found in culture broth produced by a Streptomyces species. The group includes known antimycins A1, A2, A3 and A4, and new antimycins A7 and A8. These compounds inhibit ATP-citrate lyase with Ki values of 4 to 60 microM against the substrate magnesium citrate. The structures of the new antimycins were determined by spectroscopic analyses.