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Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp

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Version 1 2017-07-26, 12:48
journal contribution
posted on 2024-06-03, 13:01 authored by Colin BarrowColin Barrow, JJ Oleynek, V Marinelli, HH Sun, P Kaplita, DM Sedlock, AM Gillum, CC Chadwick, R Cooper
A related group of compounds belonging to the antimycin class of antibiotics was found in culture broth produced by a Streptomyces species. The group includes known antimycins A1, A2, A3 and A4, and new antimycins A7 and A8. These compounds inhibit ATP-citrate lyase with Ki values of 4 to 60 microM against the substrate magnesium citrate. The structures of the new antimycins were determined by spectroscopic analyses.

History

Journal

Journal of antibiotics

Volume

50

Pagination

729-733

Location

Tokyo, Japan

Publisher DOI

Open access

  • Yes

Link to full text

ISSN

0021-8820

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1997, Japan Antibiotics Research Association

Issue

9

Publisher

Japan Antibiotics Research Association

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    Research Publications

    Categories

    Keywords

    ATP Citrate (pro-S)-LyaseAnti-Bacterial AgentsAntimycin AFermentationMolecular StructureStreptomycesStructure-Activity Relationship

    Licence

    All Rights Reserved

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