Deakin University
Browse

File(s) under permanent embargo

Antioxidants and basal cell carcinoma of the skin : a nested case-control study

journal contribution
posted on 2005-06-01, 00:00 authored by Sarah McNaughtonSarah McNaughton, G Marks, P Gaffney, G Williams, A Green
Objective To investigate the relationship between basal cell carcinoma (BCC) and antioxidant nutrients, specifically carotenoids, vitamin E and selenium.

Methods The Nambour Skin Cancer Study is an ongoing, community-based study of randomly selected adult residents of a township in sub-tropical Queensland, Australia. Using a nested case–control design, incident cases of BCC (n=90) were compared with age and sex matched controls (n=90). Dietary exposure was measured using food frequency questionnaire estimates of intake as well as serum biomarkers. Other determinants of skin cancer including sun exposure were also considered. Dietary intakes were adjusted for energy intake, and serum carotenoids and vitamin E were adjusted for serum cholesterol. Odds ratios were calculated across quartiles of dietary intake and serum biomarkers and linear trends were assessed using logistic regression, adjusting for age, sex and supplement use.

Results and conclusions In this prospective study no significant associations were found between BCC and carotenoids, vitamin E or selenium, as measured by serum biomarkers or dietary intake, although there was a suggestion of a positive association with lutein intake.

History

Journal

Cancer causes and control

Volume

16

Issue

5

Pagination

609 - 618

Publisher

Springer Netherlands

Location

Delft, The Netherlands

ISSN

0957-5243

eISSN

1573-7225

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2005, Springer