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Antithrombin III mRNA in adult rat liver and kidney and in rat liver during development

journal contribution
posted on 2023-02-07, 00:37 authored by SE D'Souza, Julian MercerJulian Mercer
Using Northern blots the size of antithrombin III (AT III) mRNA in rat liver was found to be 1650 nucleotides. Adult rat kidney also contained a slightly smaller mRNA at about 20% the level in liver. The ontogeny of AT III mRNA in the liver was assessed by dot blot hybridization. The mRNA was detectable at the ealiest age examined (14th day of gestation) at about 15% of the adult levels. After the 17th day of gestation the levels of antithrombin III mRNA rise reaching 50% of adult levels at birth. After birth the mRNA levels rise to 75% of adult levels by the 5th day and reach adult levels by 40 days after birth. We suggest that foetal AT III is produced by both the foetal liver and by placental transfer of the maternal inhibitor. © 1987.

History

Journal

Biochemical and Biophysical Research Communications

Volume

142

Pagination

417-421

Location

United States

ISSN

0006-291X

eISSN

1090-2104

Language

English

Issue

2

Publisher

ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS