bauer-anythingyoucan-2019.pdf (1.51 MB)
Anything you can do, I can do better: can aptamers replace antibodies in clinical diagnostic applications?
journal contributionposted on 2019-01-01, 00:00 authored by michelle Bauer, Mia StromMia Strom, David Hammond, Sarah ShigdarSarah Shigdar
The mainstay of clinical diagnostics is the use of specialised ligands that can recognise specific biomarkers relating to pathological changes. While protein antibodies have been utilised in these assays for the last 40 years, they have proven to be unreliable due to a number of reasons. The search for the ‘perfect’ targeting ligand or molecular probe has been slow, though the description of chemical antibodies, also known as aptamers, nearly 30 years ago suggested a replacement reagent. However, uptake has been slow to progress into the clinical environment. In this review, we discuss the issues associated with antibodies and describe some of the applications of aptamers that have relevancy to the clinical diagnostic environment.
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Publication classificationC1 Refereed article in a scholarly journal
aptamersantibodiesclinical diagnosticsimmunohistochemistryimmunophenotypinglateral flow devicesScience & TechnologyLife Sciences & BiomedicinePhysical SciencesBiochemistry & Molecular BiologyChemistry, MultidisciplinaryChemistryclinicaldiagnosticsMYCOBACTERIUM-TUBERCULOSISFLOW-CYTOMETRYDNA APTAMERSVALIDATIONSELECTIONTHERAPEUTICSGENERATIONMOLECULESENZYMEASSAYSOrganic Chemistry