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Application of dual tree complex wavelet transform in tandem mass spectrometry
journal contribution
posted on 2015-08-01, 00:00 authored by S Murugesan, David TayDavid Tay, I Cooke, P FaouMass Spectrometry (MS) is a widely used technique in molecular biology for high throughput identification and sequencing of peptides (and proteins). Tandem mass spectrometry (MS/MS) is a specialised mass spectrometry technique whereby the sequence of peptides can be determined. Preprocessing of the MS/MS data is indispensable before performing any statistical analysis on the data. In this work, preprocessing of MS/MS data is proposed based on the Dual Tree Complex Wavelet Transform (DTCWT) using almost symmetric Hilbert pair of wavelets. After the preprocessing step, the identification of peptides is done using the database search approach. The performance of the proposed preprocessing technique is evaluated by comparing its performance against Discrete Wavelet Transform (DWT) and Stationary Wavelet Transform (SWT). The preprocessing performed using DTCWT identified more peptides compared to DWT and SWT.
History
Journal
Computers in biology and medicineVolume
63Pagination
36 - 41Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0010-4825eISSN
1879-0534Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2015, ElsevierUsage metrics
Keywords
Dual tree complex wavelet transformPeptides detectionProteomic data processingSignal denoisingTandem mass spectrometryDatabases, ProteinHumansMass SpectrometryModels, ChemicalNeoplasm ProteinsNeoplasmsPeptidesScience & TechnologyLife Sciences & BiomedicineTechnologyBiologyComputer Science, Interdisciplinary ApplicationsEngineering, BiomedicalMathematical & Computational BiologyLife Sciences & Biomedicine - Other TopicsComputer ScienceEngineeringIMPROVED PEAK DETECTIONSPECTRAL DATAHILBERT-PAIRQUANTIFICATIONIDENTIFICATIONVARIANCESOFTWAREROBUSTArtificial Intelligence and Image Processing
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