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Aptamer-based therapeutic approaches to target cancer stem cells

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journal contribution
posted on 2017-01-01, 00:00 authored by G Zhou, O Latchoumanin, M Bagdesar, L Hebbard, Wei DuanWei Duan, C Liddle, J George, L Qiao
Cancer stem cells (CSCs) are believed to be a principal cellular source for tumour progression and therapeutic drug resistance as they are capable of self-renewal and can differentiate into cancer cells. Importantly, CSCs acquire the ability to evade the killing effects of cytotoxic agents through changes at the genetic, epigenetic and micro-environment levels. Therefore, therapeutic strategies targeting CSCs hold great potential as an avenue for cancer treatment. Aptamers or "chemical antibodies" are a group of single-stranded nucleic acid (DNA or RNA) oligonucleotides with distinctive properties such as smaller size, lower toxicity and less immunogenicity compared to conventional antibodies. They have been frequently used to deliver therapeutic payloads to cancer cells and have achieved encouraging anti-tumour effects. This review discusses progress in CSC evolution theory and the role of aptamers to target CSCs for cancer treatment. Challenges of aptamer-mediated CSC targeting approaches are also discussed.

History

Journal

Theranostics

Volume

7

Issue

16

Pagination

3948 - 3961

Publisher

Ivyspring International Publisher

Location

Wyoming, N.S.W.

eISSN

1838-7640

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2017, Ivyspring International Publishers