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Aptamer-guided extracellular vesicle theranostics in oncology

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Version 2 2024-06-06, 00:18
Version 1 2020-03-20, 15:44
journal contribution
posted on 2024-06-18, 20:04 authored by PHL Tran, D Xiang, TNG Nguyen, TTD Tran, Q Chen, W Yin, Y Zhang, Lingxue KongLingxue Kong, A Duan, K Chen, M Sun, Y Li, Y Hou, Y Zhu, Y Ma, G Jiang, Wei DuanWei Duan
In the past decade, the study of exosomes, nanosized vesicles (50-150 nm) released into the extracellular space via the fusion of multivesicular bodies with the plasma membrane, has burgeoned with impressive achievements in theranostics applications. These nanosized vesicles have emerged as key players in homeostasis and in the pathogenesis of diseases owing to the variety of the cargos they can carry, the nature of the molecules packaged inside the vesicles, and the robust interactions between exosomes and target cells or tissues. Accordingly, the development of exosome-based liquid biopsy techniques for early disease detection and for monitoring disease progression marks a new era of precision medicine in the 21st century. Moreover, exosomes possess intrinsic properties - a nanosized structure and unique "homing effects" - that make them outstanding drug delivery vehicles. In addition, targeted exosome-based drug delivery systems can be further optimized using active targeting ligands such as nucleic acid aptamers. Indeed, the aptamers themselves can function as therapeutic and/or diagnostic tools based on their attributes of unique target-binding and non-immunogenicity. This review aims to provide readers with a current picture of the research on exosomes and aptamers and their applications in cancer theranostics, highlighting recent advances in their transition from the bench to the clinic.

History

Journal

Theranostics

Volume

10

Pagination

3849-3866

Location

Australia

Open access

  • Yes

ISSN

1838-7640

eISSN

1838-7640

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2020, The author(s)

Issue

9

Publisher

IVYSPRING INT PUBL