Deakin University
Browse

File(s) under permanent embargo

Aptamer-mediated cancer gene therapy.

Version 2 2024-06-04, 12:09
Version 1 2015-03-24, 15:25
journal contribution
posted on 2024-06-04, 12:09 authored by D Xiang, Sarah ShigdarSarah Shigdar, G Qiao, SF Zhou, Y Li, MQ Wei, L Qiao, HA Shamaileh, Y Zhu, C Zheng, C Pu, Wei DuanWei Duan
Cancer as a genetic disorder is one of the leading causes of death worldwide. Conventional anticancer options such as chemo- and/or radio-therapy have their own drawbacks and could not provide a cure in most cases at present. More effective therapeutic strategies with less side effects are urgently needed. Aptamers, also known as chemical antibodies, are single strand DNA or RNA molecules that can bind to their target molecules with high affinity and specificity. Such site-specific binding ability of aptamers facilitates the delivery and interaction of exogenous nucleic acids with diseased genes. Thus, aptamer-guided gene therapy has emerged as a promising anticancer strategy in addition to the classic treatment regimen. Aptamers can directly deliver anti-cancer nucleic acids, e.g. small interfering RNA, micro RNA, antimicroRNA and small hairpin RNA, to cancer cells or function as a targeting ligand to guide nanoparticles containing therapeutic nucleic acids. This review focuses on recent progress in aptamer-mediated gene therapy for the treatment of hepatocellular carcinoma and other types of cancers, shedding light on the potential of this novel approach of targeted cancer gene therapy.

History

Journal

Current Gene Therapy

Volume

15

Pagination

109-119

Location

Bussum, Netherlands

eISSN

1875-5631

Language

eng

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2015, Bentham Science Publishers Ltd

Issue

2

Publisher

Bentham Science Publishers Ltd

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC