duan-aptamersapromising-2016.pdf (1.76 MB)
Aptamers: a promising chemical antibody for cancer therapy
journal contribution
posted on 2016-01-01, 00:00 authored by G Zhou, G Wilson, L Hebbard, Wei DuanWei Duan, C Liddle, J George, L QiaoAptamers, also known as chemical antibodies, are single-stranded nucleic acid oligonucleotides which bind to their targets with high specificity and affinity. They are typically selected by repetitive in vitro process termed systematic evolution of ligands by exponential enrichment (SELEX). Owing to their excellent properties compared to conventional antibodies, notably their smaller physical size and lower immunogenicity and toxicity, aptamers have recently emerged as a new class of agents to deliver therapeutic drugs to cancer cells by targeting specific cancer-associated hallmarks. Aptamers can also be structurally modified to make them more flexible in order to conjugate other agents such as nano-materials and therapeutic RNA agents, thus extending their applications for cancer therapy. This review presents the current knowledge on the practical applications of aptamers in the treatment of a variety of cancers.
History
Journal
OncotargetVolume
7Issue
12Pagination
13446 - 13463Publisher
Impact Journals LLCLocation
Albany, N.Y.Publisher DOI
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eISSN
1949-2553Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2016, Impact Journals LLCUsage metrics
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