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Aptamers as potential therapeutic agents for ovarian cancer

Version 2 2024-06-04, 13:53
Version 1 2018-06-11, 10:33
journal contribution
posted on 2018-02-01, 00:00 authored by Justin Henri, Joanna MacdonaldJoanna Macdonald, M Strom, Wei DuanWei Duan, Sarah ShigdarSarah Shigdar
Current therapy for ovarian cancer typically involves indiscriminate chemotherapies that can have severe off target effects on healthy tissue and are still plagued by aggressive recurrence. Recent shifts towards targeted therapies offer the possibility of circumventing the obstacles experienced by these traditional treatments. While antibodies are the pioneering agents in targeted therapies, clinical experience has demonstrated that their antitumor efficacy is limited due to their high immunogenicity, large molecular size, and costly and laborious production. In contrast, nucleic acid based chemical antibodies, also known as aptamers, are ideal for this application given their small size, lack of immunogenicity and in vitro production. As aptamers have begun to demonstrate their promise through targeting Epithelial Cell Adhesion Molecule (EpCAM), as well as a number of ovarian cancer biomarkers, in in vivo and in vitro models, their clinical applicability is slowly being realised. This review explores some of the current progress of aptamers targeting cancer biomarkers and their potential role as ovarian cancer therapeutics.

History

Journal

Biochimie

Volume

145

Pagination

34 - 44

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0300-9084

eISSN

1638-6183

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal