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Aptamers as theranostic agents: modifications, serum stability and functionalisation

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journal contribution
posted on 2024-06-06, 01:29 authored by Sarah ShigdarSarah Shigdar, Joanna MacdonaldJoanna Macdonald, M O'Connor, T Wang, D Xiang, H Al.Shamaileh, L Qiao, M Wei, SF Zhou, Y Zhu, Lingxue KongLingxue Kong, S Bhattacharya, C Li, Wei DuanWei Duan
Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selectionprocedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.

History

Journal

Sensors

Volume

13

Pagination

13624-13637

Location

Basel, Switzerland

Open access

  • Yes

ISSN

1424-8239

eISSN

1424-8220

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2013, M D P I AG

Issue

10

Publisher

M D P I AG