shigdar-aptamersastheranostic-2013.pdf (646.07 kB)
Aptamers as theranostic agents: modifications, serum stability and functionalisation
journal contribution
posted on 2013-10-01, 00:00 authored by Sarah ShigdarSarah Shigdar, Joanna MacdonaldJoanna Macdonald, M O'Connor, Tao Wang, D Xiang, H Al.Shamaileh, L Qiao, M Wei, S F Zhou, Y Zhu, Lingxue KongLingxue Kong, S Bhattacharya, C Li, Wei DuanWei DuanAptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selectionprocedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
History
Journal
SensorsVolume
13Issue
10Pagination
13624 - 13637Publisher
M D P I AGLocation
Basel, SwitzerlandPublisher DOI
ISSN
1424-8239eISSN
1424-8220Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2013, M D P I AGUsage metrics
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Keywords
aptamerSELEXcancerdiagnosticslocked nucleic acidunlocked nucleic acidScience & TechnologyPhysical SciencesTechnologyChemistry, AnalyticalEngineering, Electrical & ElectronicInstruments & InstrumentationChemistryEngineeringLOCKED NUCLEIC-ACIDSQUANTUM-DOTIN-VITROEXPONENTIAL ENRICHMENTSYSTEMATIC EVOLUTIONTARGET BINDINGDNA APTAMERLIVE CELLSRNADistributed ComputingEcology
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