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Aptasensors : a review
journal contribution
posted on 2010-04-01, 00:00 authored by Yang Lim, Abbas KouzaniAbbas Kouzani, Wei DuanWei DuanAptamers are a promising class of agents for biomolecules detection due to their small size, chemical stability and cost effectiveness over conventional bioreceptors such as antibodies. Recent advances in micro/nano-fabrication and biotechnology have driven active participation of engineers and molecular biologists in the development of aptasensors. This review examines aptasensors from a developer standpoint discussing surface immobilization techniques and mechanisms used to detect biomolecular interactions in the context of biotechnology and nanomedicine. The factors that affect accuracy, sensitivity and stability of aptasensors are also addressed.
History
Journal
Journal of biomedical nanotechnologyVolume
6Issue
2Pagination
93 - 105Publisher
American Scientific PublishersLocation
Valencia, Calif.ISSN
1550-7033eISSN
1550-7041Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2010, American Scientific PublishersUsage metrics
Keywords
aptasensoraptamerimmobilizationreporteropticalelectrochemicalelectricalmass-sensitivemicromechanicalScience & TechnologyTechnologyNanoscience & NanotechnologyMaterials Science, BiomaterialsScience & Technology - Other TopicsMaterials ScienceLABEL-FREE DETECTIONMOLECULAR RECOGNITIONELECTRONIC DETECTIONRNA APTAMERPROTEINSENSORDNABIOSENSORTHROMBINFIELDInorganic Chemistry
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