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Download fileAre office-based workplace interventions designed to reduce sitting time cost-effective primary prevention measures for cardiovascular disease? A systematic review and modelled economic evaluation
journal contribution
posted on 2019-03-07, 00:00 authored by Lan GaoLan Gao, Phuong NguyenPhuong Nguyen, David Dunstan, Marj MoodieMarj MoodieOBJECTIVES: To assess the cost-effectiveness of workplace-delivered interventions designed to reduce sitting time as primary prevention measures for cardiovascular disease (CVD) in Australia. METHODS: A Markov model was developed to simulate the lifetime cost-effectiveness of a workplace intervention for the primary prevention of CVD amongst office-based workers. An updated systematic review and a meta-analysis of workplace interventions that aim to reduce sitting time was conducted to inform the intervention effect. The primary outcome was workplace standing time. An incremental cost-effectiveness ratio (ICER) was calculated for this intervention measured against current practice. Costs (in Australia dollars) and benefits were discounted at 3% annually. Both deterministic (DSA) and probabilistic (PSA) sensitivity analyses were performed. RESULTS: The updated systematic review identified only one new study. Only the multicomponent intervention that included a sit-and-stand workstation showed statistically significant changes in the standing time compared to the control. The intervention was associated with both higher costs ($6820 versus $6524) and benefits (23.28 versus 23.27, quality-adjusted life year, QALYs), generating an ICER of $43,825/QALY. The DSA showed that target age group for the intervention, relative risk of CVD relative to the control and intervention cost were the key determinants of the ICER. The base case results were within the range of the 95% confidence interval and the intervention had a 85.2% probability of being cost-effective. CONCLUSIONS: A workplace-delivered intervention in the office-based setting including a sit-and-stand desk component is a cost-effective strategy for the primary prevention of CVD. It offers a new option and location when considering interventions to target the growing CVD burden.
History
Journal
International journal of environmental research and public healthVolume
16Issue
5Publisher
MDPILocation
Basel, SwitzerlandPublisher DOI
Link to full text
ISSN
1661-7827eISSN
1660-4601Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2019, The AuthorsUsage metrics
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Categories
Keywords
cardiovascular diseasecost-effective analysismulticomponentprimary preventionsedentary behaviourworkplace interventionScience & TechnologyLife Sciences & BiomedicineEnvironmental SciencesPublic, Environmental & Occupational HealthEnvironmental Sciences & EcologyALL-CAUSE MORTALITYSEDENTARY TIMERISKASSOCIATIONBIOMARKERSBEHAVIORSAUSTRALIAADULTS