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Assessing cerebellar brain inhibition (CBI) via transcranial magnetic stimulation (TMS): a systematic review

journal contribution
posted on 01.03.2018, 00:00 authored by Lara Fernandez, Brendan Major, Wei-Peng TeoWei-Peng Teo, Linda ByrneLinda Byrne, Peter EnticottPeter Enticott
The inhibitory tone that the cerebellum exerts on the primary motor cortex (M1) is known as cerebellar brain inhibition (CBI). Studies show CBI to be relevant to several motor functions, including adaptive motor learning and muscle control. CBI can be assessed noninvasively via transcranial magnetic stimulation (TMS) using a double-coil protocol. Variability in parameter choice and controversy surrounding the protocol's ability to isolate the cerebellothalamocortical pathway casts doubt over its validity in neuroscience research. This justifies a systematic review of both the protocol, and its application. The following review examines studies using the double-coil protocol to assess CBI in healthy adults. Parameters and CBI in relation to task-based studies, other non-invasive protocols, over different muscles, and in clinical samples are reviewed. Of the 1398 studies identified, 24 met selection criteria. It was found that methodological design and selection of parameters in several studies may have reduced the validity of outcomes. Further systematic testing of CBI protocols is warranted, both from a parameter and task-based perspective.

History

Journal

Neuroscience and biobehavioral reviews

Volume

86

Pagination

176 - 206

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0149-7634

eISSN

1873-7528

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2017, Elsevier