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Assessing cerebellar brain inhibition (CBI) via transcranial magnetic stimulation (TMS): a systematic review
journal contribution
posted on 2018-03-01, 00:00 authored by Lara Fernandez, Brendan Major, Wei-Peng TeoWei-Peng Teo, Linda ByrneLinda Byrne, Peter EnticottPeter EnticottThe inhibitory tone that the cerebellum exerts on the primary motor cortex (M1) is known as cerebellar brain inhibition (CBI). Studies show CBI to be relevant to several motor functions, including adaptive motor learning and muscle control. CBI can be assessed noninvasively via transcranial magnetic stimulation (TMS) using a double-coil protocol. Variability in parameter choice and controversy surrounding the protocol's ability to isolate the cerebellothalamocortical pathway casts doubt over its validity in neuroscience research. This justifies a systematic review of both the protocol, and its application. The following review examines studies using the double-coil protocol to assess CBI in healthy adults. Parameters and CBI in relation to task-based studies, other non-invasive protocols, over different muscles, and in clinical samples are reviewed. Of the 1398 studies identified, 24 met selection criteria. It was found that methodological design and selection of parameters in several studies may have reduced the validity of outcomes. Further systematic testing of CBI protocols is warranted, both from a parameter and task-based perspective.
History
Journal
Neuroscience and biobehavioral reviewsVolume
86Pagination
176 - 206Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0149-7634eISSN
1873-7528Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, ElsevierUsage metrics
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No categories selectedKeywords
AdaptationCerebellar brain inhibitionCerebellumDouble-cone coilFigure-of-8 coilICFLICILTDMotor learningPASPurkinje cellSICITBSTMSTolerabilityrTMStACStDCSScience & TechnologyLife Sciences & BiomedicineBehavioral SciencesNeurosciencesNeurosciences & NeurologyMOTOR CORTICAL EXCITABILITYPROGRESSIVE SUPRANUCLEAR PALSYTHETA-BURST STIMULATIONSENSORY PREDICTION ERRORSLONG-TERM DEPRESSIONVISUOMOTOR ADAPTATIONCORTICOSPINAL TRACTCOGNITIVE FUNCTIONINTERNAL-MODELSDENTATE NUCLEUS
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