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Assessment of cerebrovascular responses to physiological stimuli in identical twins using multimodal imaging and computational fluid dynamics

Version 2 2024-06-06, 10:44
Version 1 2023-04-28, 06:42
journal contribution
posted on 2024-06-06, 10:44 authored by Hannah J Thomas, Usaid Rana, Channa E Marsh, Harrison T Caddy, Lachlan J Kelsey, Kurt J Smith, Daniel J Green, Barry J Doyle
There is acknowledged variability in the Circle of Willis in the general population, yet the structure and function relationship of the cerebrovasculature is poorly understood. Using a combination of magnetic resonance imaging, high-resolution Doppler ultrasound, and computational fluid dynamic modeling, we show that monozygotic twins exhibit differences in cerebrovascular structure and function when exposed to physiological stimuli. These data suggest that the morphology, function, and health of cerebrovascular arteries are not primarily genetically determined.

History

Journal

Journal of Applied Physiology

Volume

129

Pagination

1024-1032

Location

Bethesda, Md.

ISSN

8750-7587

eISSN

1522-1601

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

5

Publisher

American Physiological Society

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