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Assessment of cerebrovascular responses to physiological stimuli in identical twins using multimodal imaging and computational fluid dynamics
journal contribution
posted on 2023-04-28, 06:42 authored by Hannah Thomas, Usaid Rana, Channa E Marsh, Harrison T Caddy, Lachlan J Kelsey, Kurt J Smith, Daniel J Green, Barry J DoyleThere is acknowledged variability in the Circle of Willis in the general population, yet the structure and function relationship of the cerebrovasculature is poorly understood. Using a combination of magnetic resonance imaging, high-resolution Doppler ultrasound, and computational fluid dynamic modeling, we show that monozygotic twins exhibit differences in cerebrovascular structure and function when exposed to physiological stimuli. These data suggest that the morphology, function, and health of cerebrovascular arteries are not primarily genetically determined.
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Journal
Journal of Applied PhysiologyVolume
129Pagination
1024-1032Location
United StatesPublisher DOI
ISSN
8750-7587eISSN
1522-1601Language
enPublication classification
C1.1 Refereed article in a scholarly journalIssue
5Publisher
American Physiological SocietyUsage metrics
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No categories selectedKeywords
cerebrovasculaturecomputational fluid dynamicsfunctionshear stressstructureBlood Flow VelocityCerebrovascular CirculationComputer SimulationHemodynamicsHumansHydrodynamicsModels, CardiovascularMultimodal ImagingTwins, MonozygoticBrain DisordersClinical ResearchCardiovascularNeurosciencesBiological SciencesMedical and Health Sciences
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