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Assessment of fracture risk : value of random population-based samples - the Geelong Osteoporosis Study
journal contribution
posted on 2001-01-01, 00:00 authored by Margaret Rogers, Julie PascoJulie Pasco, E Seeman, G Nicholson, K Sanders, Mark KotowiczMark KotowiczFracture risk is determined by bone mineral density (BMD). The T-score, a measure of fracture risk, is the position of an individual's BMD in relation to a reference range. The aim of this study was to determine the magnitude of change in the T-score when different sampling techniques were used to produce the reference range. Reference ranges were derived from three samples, drawn from the same region: (1) an age-stratified population-based random sample, (2) unselected volunteers, and (3) a selected healthy subset of the population-based sample with no diseases or drugs known to affect bone. T-scores were calculated using the three reference ranges for a cohort of women who had sustained a fracture and as a group had a low mean BMD (ages 35-72 yr; n = 484). For most comparisons, the T-scores for the fracture cohort were more negative using the population reference range. The difference in T-scores reached 1.0 SD. The proportion of the fracture cohort classified as having osteoporosis at the spine was 26, 14, and 23% when the population, volunteer, and healthy reference ranges were applied, respectively. The use of inappropriate reference ranges results in substantial changes to T-scores and may lead to inappropriate management.
History
Journal
Journal of clinical densitometryVolume
4Issue
4Season
WinterPagination
283 - 289Publisher
Elsevier B.V.Location
Amsterdam, The NetherlandsPublisher DOI
ISSN
1094-6950eISSN
1559-0747Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2001, Elsevier B.V.Usage metrics
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