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Association between 5-HTTLPR genotypes and persisting patterns of anxiety and alcohol use : results from a 10-year longitudinal study of adolescent mental health
journal contribution
posted on 2005-09-01, 00:00 authored by Craig OlssonCraig Olsson, G Byrnes, M Lotfi-Miri, V Collins, B Williamson, C Patton, R AnneyThe serotonin transporter gene (5-HTT) encodes a transmembrane protein that plays an important role in regulating serotonergic neurotransmission and related aspects of mood and behaviour. The short allele of a 44 bp insertion/deletion polymorphism (S-allele) within the promoter region of the 5-HTT gene (5-HTTLPR) confers lower transcriptional activity relative to the long allele (L-allele) and may act to modify the risk of serotonin-mediated outcomes such as anxiety and substance use behaviours. The purpose of this study was to determine whether (or not) 5-HTTLPR genotypes moderate known associations between attachment style and adolescent anxiety and alcohol use outcomes. Participants were drawn from an eight-wave study of the mental and behavioural health of a cohort of young Australians followed from 14 to 24 years of age (Victorian Adolescent Health Cohort Study, 1992 - present). No association was observed within low-risk attachment settings. However, within risk settings for heightened anxiety (ie, insecurely attached young people), the odds of persisting ruminative anxiety (worry) decreased with each additional copy of the S-allele (B30% per allele: OR 0.77, 95% CI 0.62–0.97, P¼0.029). Within risk settings for binge drinking (ie, securely attached young people), the odds of reporting persisting high-dose alcohol consumption (bingeing) decreased with each additional copy of the S-allele (B35% per allele: OR 0.74, 95% CI 0.64–0.86, Po0.001). Our data suggest that the S-allele is likely to be important in psychosocial development, particularly in those settings that increase risk of anxiety and alcohol use problems.
History
Journal
Molecular psychiatryVolume
10Issue
9Pagination
868 - 876Publisher
Nature Publishing GroupLocation
London, U. K.Publisher DOI
ISSN
1359-4184eISSN
1476-5578Language
engNotes
First published online 26 April 2005Publication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2005, Nature Publishing GroupUsage metrics
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5-HTTLPRgene–environment interactionadolescenceanxietyalcoholScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyNeurosciencesPsychiatryNeurosciences & Neurologygene-environment interactionSEROTONIN TRANSPORTER GENEDEFICIT HYPERACTIVITY DISORDERBIPOLAR AFFECTIVE-DISORDERLINKED POLYMORPHIC REGIONATTENTION-DEFICITAUTISTIC DISORDERFUNCTIONAL POLYMORPHISMPROMOTER POLYMORPHISMREGULATORY REGIONBEHAVIOR PROBLEMS
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