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Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

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Version 2 2024-06-04, 13:36
Version 1 2018-08-10, 12:49
journal contribution
posted on 2024-06-04, 13:36 authored by Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Kirsi H Pietiläinen, Yoon-Mi Hur, Gonneke Willemsen, Meike Bartels, Toos CEM van Beijsterveldt, Syuichi Ooki, Kimberly J Saudino, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Tracy L Nelson, Keith E Whitfield, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Kauko Heikkilä, Tessa L Cutler, John L Hopper, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Ruth JF Loos, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D Tarnoki, David L Tarnoki, S Alexandra Burt, Kelly L Klump, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Jeffrey CraigJeffrey Craig, Richard Saffery, Finn Rasmussen, Per Tynelius, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Claire MA Haworth, Robert Plomin, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Robert F Krueger, Matt McGue, Shandell Pahlen, Dorret I Boomsma, Thorkild IA Sørensen, Jaakko Kaprio, Karri Silventoinen
Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses. Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m2 higher BMI (P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m2 per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood. Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.

History

Journal

International journal of epidemiology

Volume

46

Pagination

1488-1498

Location

Oxford, Eng.

ISSN

0300-5771

eISSN

1464-3685

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2017, The Authors

Issue

5

Publisher

Oxford University Press