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Association of lipoprotein(a) with long-term mortality following coronary angiography or percutaneous coronary intervention

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Version 2 2024-06-04, 12:34
Version 1 2018-06-07, 13:04
journal contribution
posted on 2024-06-04, 12:34 authored by Z Feng, HL Li, WJ Bei, XS Guo, K Wang, SX Yi, DM Luo, XD Li, SQ Chen, P Ran, PY Chen, Shariful IslamShariful Islam, JY Chen, Y Liu, YL Zhou
BACKGROUND: There is no consistent evidence to suggest the association of plasma lipoprotein(a) (Lp[a]) with long-term mortality in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI). HYPOTHESIS: Level of Lp(a) is associated with long-term mortality following CAG or PCI. METHODS: We enrolled 1684 patients with plasma Lp(a) data undergoing CAG or PCI between April 2009 and December 2013. The patients were divided into 2 groups: a low-Lp(a) group (Lp[a] <16.0 mg/dL; n = 842) and a high-Lp(a) group (Lp[a] ≥16.0 mg/dL; n = 842). RESULTS: In-hospital mortality was not significantly different between the high and low Lp(a) groups (0.8% vs 0.5%, respectively; P = 0.364). During the median follow-up period of 1.95 years, the high-Lp(a) group had a higher long-term mortality than did the low-Lp(a) group (5.8% vs 2.5%, respectively; P = 0.003). After adjustment of confounders, multivariate Cox regression analysis revealed that a higher Lp(a) level was an independent predictor of long-term mortality (hazard ratio: 1.96, 95% confidence interval: 1.07-3.59, P = 0.029). CONCLUSIONS: Our data suggested that an elevated Lp(a) level was significantly associated with long-term mortality following CAG or PCI. However, additional larger multicenter studies will be required to investigate the predictive value of Lp(a) levels and evaluate the benefit of controlling Lp(a) levels for patients undergoing CAG or PCI.

History

Journal

Clinical Cardiology

Volume

40

Pagination

674-678

Location

United States

ISSN

0160-9289

eISSN

1932-8737

Language

English

Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Copyright notice

2017, Wiley

Issue

9

Publisher

WILEY