huxley-associationsbetweenhigh-2007.pdf (244.04 kB)
Associations between high-density lipoprotein cholesterol and both stroke and coronary heart disease in the Asia Pacific region
journal contribution
posted on 2007-11-01, 00:00 authored by Mark Woodward, Federica Barzi, Valery Feigin, Dongfeng Gu, Rachel HuxleyRachel Huxley, Koshi Nakamura, Anushka Patel, Suzanne Ho, Konrad JamrozikBackground: The inverse relationship between high-density lipoprotein (HDL) cholesterol and coronary heart disease (CHD) is well established. Questions remain about the association between HDL cholesterol and stroke, particularly for stroke subtypes. Methods and results: Cox survival models were applied to individual participant data from 25 cohort studies (about 80 000 subjects), with a median of 6.8 years follow-up. After adjustment for age and regression dilution, hazard ratios (95% confidence intervals) for a 1 standard deviation (SD) lower level of HDL cholesterol (0.4 mmol/L) were: for CHD events, 1.39 (1.22-1.57); for ischaemic stroke, 0.90 (0.75-1.07), and for haemorrhagic stroke, 0.89 (0.74-1.07). As total cholesterol (TC) increased relative to HDL cholesterol, the risk of CHD increased, the risk of ischaemic stroke was unchanged but the risk of haemorrhagic stroke decreased. A 1 SD increase in TC/HDL cholesterol (1.63 units) was associated with a 27% decrease in the risk of haemorrhagic stroke (95% confidence interval, 7-44%). Conclusion: There is clear evidence of potential benefit for CHD of increases in HDL cholesterol and decreases in TC relative to HDL cholesterol, but no evidence of an association between either HDL cholesterol or TC/HDL cholesterol and ischaemic stroke. Increasing HDL cholesterol relative to TC may increase the risk of haemorrhagic stroke.
History
Journal
European Heart JournalVolume
28Issue
21Pagination
2653 - 2660Publisher
Oxford University PressLocation
Oxford, Eng.Publisher DOI
ISSN
0195-668XeISSN
1522-9645Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2007, The AuthorsUsage metrics
Categories
No categories selectedKeywords
cholesterolcoronary diseasestrokelipidsScience & TechnologyLife Sciences & BiomedicineCardiac & Cardiovascular SystemsCardiovascular System & CardiologyISCHEMIC-STROKERISK-FACTORSHEMORRHAGIC STROKESERUM-CHOLESTEROLBLOOD-PRESSUREFOLLOW-UPMENINFARCTIONMORTALITYAsia Pacific Cohort Studies Collaboration
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC