Deakin University
Browse

File(s) under permanent embargo

Associations between multi-method latent factors of puberty and brain structure in adolescent girls

journal contribution
posted on 2023-03-27, 03:56 authored by ML Byrne, Nandi VijayakumarNandi Vijayakumar, SJ Chavez, JC Flournoy, TW Cheng, KL Mills, MEA Barendse, A Mobasser, JE Flannery, BW Nelson, W Wang, EA Shirtcliff, NB Allen, JH Pfeifer
Pubertal processes are associated with structural brain development, but studies have produced inconsistent findings that may relate to different measurements of puberty. Measuring both hormones and physical characteristics is important for capturing variation in neurobiological development. The current study explored associations between cortical thickness and latent factors from multi-method pubertal data in 174 early adolescent girls aged 10–13 years in the Transitions in Adolescent Girls (TAG) Study. Our multi-method approach used self-reported physical characteristics and hormone levels (dehydroepiandrosterone (DHEA), testosterone (T), and estradiol (E2) from saliva) to estimate an overall pubertal factor and for each process of adrenarche and gonadarche. There were negative associations between the overall puberty factor representing later stage and thickness in the posterior cortex, including the occipital cortices and extending laterally to the parietal lobe. However, the multi-method latent factor had weaker cortical associations when examining the adnearcheal process alone, suggesting physical characteristics and hormones capture different aspects of neurobiological development during adrenarche. Controlling for age weakened some of these associations. These findings show that associations between pubertal stage and cortical thickness differ depending on the measurement method and the pubertal process, and both should be considered in future confirmatory studies on the developing brain.

History

Journal

Developmental Cognitive Neuroscience

Volume

60

Article number

101228

Pagination

101228-101228

Location

Netherlands

ISSN

1878-9293

eISSN

1878-9307

Language

en

Publisher

Elsevier BV