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Associations of obsessive-compulsive symptoms with clinical and neurocognitive features in schizophrenia according to stage of illness

Version 2 2024-05-30, 15:33
Version 1 2015-03-17, 16:03
journal contribution
posted on 2024-05-30, 15:33 authored by SW Kim, BO Jeong, JM Kim, IS Shin, MY Hwang, G Paul Amminger, B Nelson, Michael BerkMichael Berk, P McGorry, JS Yoon
This study aimed to investigate the association of obsessive-compulsive symptoms with clinical and neurocognitive features in patients with schizophrenia. This study enrolled 163 people with schizophrenia who were receiving risperidone monotherapy. Comorbid obsessive-compulsive symptoms were assessed using the Yale-Brown Obsessive-Compulsive Scale, and subjects with a score ≥ 10 constituted the obsessive-compulsive symptom group (n=30, 18.4%). The learning index was significantly higher in patients with obsessive-compulsive symptoms than in those without such symptoms after adjusting for age, stage (early and chronic), duration of illness, and CDSS score. However, there was no significant interaction between obsessive-compulsive symptoms and stage of illness. Scores on Positive and Negative Syndrome Scale, Calgary Depression Scale for Schizophrenia, and Beck Depression Inventory were significantly higher in the obsessive-compulsive symptom group. In addition, the Subjective Well-being under Neuroleptic Treatment score was significantly lower in the obsessive-compulsive symptom group. In conclusion, comorbid obsessive-compulsive symptoms in patients with schizophrenia were associated with a higher learning ability without a significant interaction with stage of illness. However, schizophrenia patients with obsessive-compulsive symptoms had more severe psychotic and depressive symptoms and poorer quality of life.

History

Journal

Psychiatry research

Volume

226

Pagination

368-375

Location

Shannon, Ireland

ISSN

1872-7123

eISSN

1872-7123

Language

eng

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2015, Elsevier

Issue

1

Publisher

Elsevier