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Attenuating PI3K/Akt- mTOR pathway reduces dihydrosphingosine 1 phosphate mediated collagen synthesis and hypertrophy in primary cardiac cells
journal contribution
posted on 2021-05-01, 00:00 authored by R R Magaye, Feby SaviraFeby Savira, Y Hua, X Xiong, L Huang, C Reid, B L Flynn, D Kaye, D Liew, B H WangAttenuating PI3K/Akt- mTOR pathway reduces dihydrosphingosine 1 phosphate mediated collagen synthesis and hypertrophy in primary cardiac cells
History
Journal
International Journal of Biochemistry and Cell BiologyVolume
134Article number
105952Pagination
1 - 16Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
1357-2725eISSN
1878-5875Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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Categories
Keywords
AktBiochemistry & Molecular BiologyCardiac remodellingCell BiologyDihydrosphingosine 1 phosphateFIBROBLASTSFibrosisGATA4GLYCOGEN-SYNTHASE KINASE-3-BETAHEARTHypertrophyINHIBITIONLife Sciences & BiomedicineMICEmTORPHOSPHORYLATIONPI3KProtein kinase BRECEPTOR STIMULATIONRibosomal protein S6Science & TechnologySphingolipidSPHINGOSINE-1-PHOSPHATETRANSCRIPTIONProtein kinase B\/Akt