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Behavioral variant frontotemporal dementia performance on a range of saccadic tasks
journal contribution
posted on 2018-01-01, 00:00 authored by Amanda DouglassAmanda Douglass, Mark Walterfang, Dennis Velakoulis, Larry AbelLarry AbelBACKGROUND: Saccadic paradigms display changes across a number of degenerative conditions reflecting changes in the oculomotor pathway which in some conditions have been linked to disease presentation. OBJECTIVE: To examine a novel range of saccadic paradigms in behavioral variant frontotemporal dementia (bvFTD). METHODS: Prosaccade, predictive, self-paced, memory-guided, and anti-saccade tasks were examined in bvFTD patients and controls. RESULTS: A significant increase in latency for the bvFTD group was seen in all tasks. Self-paced saccades are reduced in number, memory-guided saccades display an increase in errors. Predictive saccades show an increased latency that does not remain when prosaccade latency changes are accounted for. While changes were seen across a range of paradigms, no individual task completely separated bvFTD from control participants. CONCLUSION: bvFTD patients as a group display a number of changes on saccadic testing which may reflect the frontal lobe changes seen in this condition.
History
Journal
Journal of alzheimer's diseaseVolume
65Issue
1Pagination
231 - 242Publisher
IOS PressLocation
Amsterdam, The NetherlandsPublisher DOI
eISSN
1875-8908Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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No categories selectedKeywords
Dementiaeye movementssaccadesScience & TechnologyLife Sciences & BiomedicineNeurosciencesNeurosciences & NeurologyMOTOR-NEURON DISEASESLOW VERTICAL SACCADESFRONTAL EYE-FIELDLOBAR DEGENERATIONALZHEIMERS-DISEASENEUROPSYCHIATRIC PATIENTSDIAGNOSTIC-CRITERIAINHIBITORY CONTROLEXECUTIVE FUNCTIONSEMANTIC DEMENTIA
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