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Behavioural characteristics of the Prader-Willi syndrome related biallelic Snord116 mouse model

journal contribution
posted on 2015-10-01, 00:00 authored by Jerzy Zieba, Jac Kee Low, Louise Purtell, Yue Qi, Lesley Campbell, Herbert Herzog, Tim Karl
Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric function, reduced activity, and learning disabilities. It can include mood instability and, in some cases, psychotic episodes. Recently, the Snord116 gene has been associated with the development of PWS, however, it's contribution to the behavioural aspects of the disease are unknown. Here we show that male and female mice lacking Snord116 on both alleles exhibit normal motor behaviours and exploration but do display task-dependent alterations to locomotion and anxiety-related behaviours. Sociability is well developed in Snord116 deficient mice as are social recognition memory, spatial working memory, and fear-associated behaviours. No sex-specific effects were found. In conclusion, the biallelic Snord116 deficiency mouse model exhibits particular endophenotypes with some relevance to PWS, suggesting partial face validity for the syndrome.

History

Journal

Neuropeptides

Volume

53

Pagination

71-77

Location

Amsterdam, The Netherlands

ISSN

0143-4179

eISSN

1532-2785

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2015, Elsevier Ltd.

Publisher

Elsevier