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Benzomalvin D, a new 1,4-benzodiazepine atropisomer

journal contribution
posted on 1995-10-01, 00:00 authored by H H Sun, Colin BarrowColin Barrow, R Cooper
A new compound, benzomalvin D [5], isolated from a fungal culture of Penicillium sp., is an atropisomer of the previously reported benzomalvin A [1] . Benzomalvins A [1] and D [5] interconvert to form a 4:1 mixture at room temperature and are totally separable by hplc. This equilibrium phenomenon was further explored through total synthesis of benzomalvin A [1] and related compounds, leading to the first report of natural atropisomers of 1,4-benzodiazepines.

History

Journal

Journal of natural products

Volume

58

Issue

10

Pagination

1575 - 1580

Publisher

American Chemical Society

Location

Washington, D.C.

ISSN

0163-3864

eISSN

1520-6025

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1995, American Chemical Society