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Benzomalvin D, a new 1,4-benzodiazepine atropisomer
journal contributionposted on 1995-10-01, 00:00 authored by H H Sun, Colin BarrowColin Barrow, R Cooper
A new compound, benzomalvin D , isolated from a fungal culture of Penicillium sp., is an atropisomer of the previously reported benzomalvin A  . Benzomalvins A  and D  interconvert to form a 4:1 mixture at room temperature and are totally separable by hplc. This equilibrium phenomenon was further explored through total synthesis of benzomalvin A  and related compounds, leading to the first report of natural atropisomers of 1,4-benzodiazepines.