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Bifrontal active and sham rTMS in treatment-resistant unipolar major depression

journal contribution
posted on 2018-01-01, 00:00 authored by Minna Valkonen-Korhonen, Hanna Leinola, Mervi Könönen, Eini Niskanen, Maija Purhonen, Maarit Pakarinen, Anu RuusunenAnu Ruusunen, Soili M Lehto, Esa Mervaala, Kirsi Honkalampi, Heli Koivumaa-Honkanen, Heimo Viinamäki
BACKGROUND AND AIM: Prevention of the recurrence of major depression and its residual symptoms requires effective treatment. Our aim was to study the effects of bifrontal active rTMS controlled by sham rTMS in treatment-resistant unipolar major depressive disorder (MDD). METHODS: Thirty-seven patients with treatment-resistant MDD were randomized into two groups. One group received a total of 30 sessions of active bifrontal rTMS (10 Hz rTMS on left dorsolateral prefrontal cortex (DLPFC) and 1 Hz rTMS on right DLPFC) and the other group received bilateral sham rTMS on five days a week for six weeks. RESULTS: Depressive symptoms significantly improved in both the groups, but without a significant group difference. Furthermore, patients with psychotic depression improved similarly to those with moderate or severe depression. CONCLUSIONS: The results of present study indicate a large sham effect of stimulation treatment. The intensive structured treatment protocol may explain the positive outcome in both the groups. It is important to recognize, appreciate, and utilize placebo effects as a significant means of rehabilitation in psychiatric care.

History

Journal

Nordic journal of psychiatry

Volume

72

Issue

8

Pagination

586 - 592

Publisher

Taylor & Francis

Location

London, Eng.

eISSN

1502-4725

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, The Nordic Psychiatric Association