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Biodegradable metal-derived Magnesium and Sodium enhances bone regeneration by angiogenesis aided osteogenesis and regulated biological apatite formation

journal contribution
posted on 2020-11-04, 00:00 authored by Yang Liu, Huafang Li, Jiankun Xu, Jessica TerBush, Wenting Li, Mohan Setty, Shaokang Guan, Thanh D Nguyen, Ling Qin, Yufeng Zheng
Biodegradable metals have great attraction to become orthopaedic implants. Here, we demonstrated a biodegradable magnesium alloy incorporated with essential element sodium through Sn-Na master alloying technique. The designed MgSnZnNa alloy presented better mechanical property and corrosion resistance due to the uniform distribution of Na in Mg2Sn second phase and solid soluble Zn in Mg matrix. The co-release of Mg and Na ions resulted in advanced upregulation of osterix and osteocalcin expression in adipose derived stem cells in vitro. It significantly promoted the rat calvarial defect bone regeneration through osteogenesis and angiogenesis, attributed to the co-release of Na and Mg ions, by increasing the expression of calcitonin gene-related peptide, osteocalcin as well as vascular endothelial growth factor. The current study provided an innovative approach by using master alloy to incorporate essential elements (such as Na or K) for fabricating biodegradable Mg alloys with reduced galvanic corrosion and enhanced biological functions.

History

Journal

Chemical Engineering Journal

Article number

127616

Location

Amsterdam, The Netherlands

ISSN

1385-8947

Language

eng

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2020, Elsevier B.V.

Issue

In-Press

Publisher

Elsevier