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Biodistribution and in vivo performance of fattigation-platform theranostic nanoparticles.
journal contribution
posted on 2017-10-01, 00:00 authored by T T-D Tran, Phuong TranPhuong Tran, H H Amin, B-J LeeThis study was aimed at characterizing superparamagnetic nanoparticles surface-functionalized with gelatin-oleic acid (GOAS-MNPs) and loaded with paclitaxel by assessing the pharmacokinetics and biodistribution of paclitaxel in tissues and the in vivo efficacy of antitumor activity after the administration of the drug. Initially, instrumental analysis was performed to examine the particle size distribution, surface charge, and morphology of the paclitaxel-loaded GOAS-MNPs. Furthermore, we evaluated their magnetic properties and performed T2-weighted magnetic resonance imaging (MRI) on cells. We intravenously administered Taxol® and paclitaxel-loaded GOAS-MNPs and compared the pharmacokinetics, biodistribution, and antitumor efficacies of the two formulations. Determination of the pharmacokinetics and the biodistribution of paclitaxel-loaded NPs showed that this formulation increased the systemic circulation time of paclitaxel and regulated its transport to tissues. The in vivo antitumor efficacy of the paclitaxel-loaded NPs was better than that of Taxol® at the same dose. Furthermore, the paclitaxel-loaded GOAS-MNPs were found to be effective as contrast agents for enhanced MRI in cancer cells. Thus, GOAS-MNPs could be an effective diagnostic system for cancer and for the delivery of paclitaxel with better therapeutic effects and a significant reduction in toxicity.
History
Journal
Materials Science and Engineering: CVolume
79Pagination
671 - 678Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0928-4931eISSN
1873-0191Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, Elsevier B.V.Usage metrics
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No categories selectedKeywords
Acute toxicityAntitumor efficacyDrug deliveryPaclitaxelSurface-functionalized magnetic nanoparticlesScience & TechnologyTechnologyMaterials Science, BiomaterialsMaterials ScienceIRON-OXIDE NANOPARTICLESDRUG-DELIVERYOLEIC-ACIDPACLITAXEL BIOAVAILABILITYPLGA NANOPARTICLESVITROPHARMACOKINETICSPERMEABILITYFORMULATIONALBUMIN
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