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Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression
journal contributionposted on 2018-07-01, 00:00 authored by Josh Price, Carrie Bronars, Sophie Erhardt, Kathyrn R Cullen, Lilly Schwieler, Michael BerkMichael Berk, Ken WalderKen Walder, Sean McgeeSean Mcgee, Mark A Frye, Susannah J Tye
Disruptions of bioenergetic signaling and neurogenesis are hallmarks of depression physiology and are often the product of dysregulation of the inflammatory, stress-response, and metabolic systems. These systems are extensively interrelated at the physiological level, yet the bulk of the literature to date addresses pathophysiological mechanisms in isolation. A more integrated understanding of the etiology, progression, and treatment response profiles of depression is possible through wider consideration of relevant preclinical and clinical studies that examine the result of disruptions in these systems. Here, we review recent data demonstrating the critical effects of bioenergetic disruption on neuroplasticity and the development and progression of depressive illness. We further highlight the interactive and dynamic nature of the inflammatory and stress response systems and how disruption of these systems influences bioenergetic signaling pathways critical to treatment outcomes. In so doing, we underscore the pressing need to reconsider the implications of treatment resistance and present a framework for developing novel, personalized treatment approaches for depression.
JournalNeuroscience and biobehavioral reviews
Pagination212 - 220
LocationAmsterdam, The Netherlands
Publication classificationC1 Refereed article in a scholarly journal
Copyright notice2018, Elsevier Ltd.
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BioenergeticsStressInflammationMetabolismKynurenineMajor depressive disorder (MDD)Bipolar disorder (BD)Proinflammatory cytokineHypothalamic-pituitary-adrenal axis (HPA axis)Brain-derived neurotrophic factor (BDNF)Mammalian target of rapamycin (mTOR)Science & TechnologyLife Sciences & BiomedicineBehavioral SciencesNeurosciencesNeurosciences & NeurologyC-REACTIVE PROTEININDOLEAMINE 2,3-DIOXYGENASEKYNURENINE METABOLISMNEUROTROPHIC FACTORPHYSICAL-ACTIVITYOXIDATIVE STRESSCONTROLLED-TRIALANIMAL-MODELEXERCISE