File(s) under permanent embargo

Biological sex influences antibody responses to routine vaccinations in the first year of life

journal contribution
posted on 2020-01-01, 00:00 authored by P Zimmermann, K P Perrett, N Ritz, K L Flanagan, R Robins-Browne, F R M van der Klis, N Curtis, V Abruzzo, K Allen, R Bonnici, D Casalaz, H Elborough, B Freyne, K Gardiner, S Germano, T Kollmann, N Messina, C Morrison, H Nakaya, A L Ponsonby, F Shann, M South, Peter VuillerminPeter Vuillermin
Aim: We investigated the effect of early-life factors, namely sex, delivery mode, feeding method and antibiotic exposure, on antibody responses to routine vaccinations administered during the first year of life. Methods: One and seven months after the primary course of routine vaccines and 1 month after routine vaccines at 12 months of age, antibodies against 26 vaccine antigens were measured in 398 healthy infants. The geometric mean concentration (GMC) of antibodies (adjusted for effect modifiers with multiple linear regression) and the seroprotection rate for each vaccine were compared for each early-life factor. Results: Sex had an influence on GMCs. Antibody concentrations were significantly lower at 7 months of age in females for tetanus and filamentous haemagglutinin and at 13 months of age for pertactin. In contrast, at 13 months of age, antibody concentrations were significantly higher in females for polio type 3, pneumococcal serotype 6A and measles. Sex did not have an influence on seroprotection rates. Delivery mode, feeding method and antibiotic exposure did not exert a substantial influence on vaccine antibody concentrations. Conclusion: There is a difference between males and females in the humoral response to routine vaccinations in the first year of life.

History

Journal

Acta paediatrica, international journal of paediatrics

Volume

109

Issue

1

Pagination

147 - 157

Publisher

Wiley

Location

Chichester, Eng.

ISSN

0803-5253

eISSN

1651-2227

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, Foundation Acta Pædiatrica