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Biomimetic modification of porous TiNbZr alloy scaffold for bone tissue engineering

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Version 2 2024-06-03, 10:57
Version 1 2014-10-28, 09:06
journal contribution
posted on 2024-06-03, 10:57 authored by X Wang, Y Li, Peter HodgsonPeter Hodgson, C Wen
Porous titanium (Ti) and Ti alloys are important scaffold materials for bone tissue engineering. In the present study, a new type of porous Ti alloy scaffold with biocompatible alloying elements, that is, niobium (Nb) and zirconium (Zr), was prepared by a space-holder sintering method. This porous TiNbZr scaffold with a porosity of 69% exhibits a mechanical strength of 67MPa and an elastic modulus of 3.9GPa, resembling the mechanical properties of cortical bone. To improve the osteoconductivity, a calcium phosphate (Ca/P) coating was applied to the surface of the scaffold using a biomimetic method. The biocompatibility of the porous TiNbZr alloy scaffold before and after the biomimetic modification was assessed using the SaOS2 osteoblast–like cells. Cell culture results indicated that the porous TiNbZr scaffold is more favorable for cell adhesion and proliferation than its solid counterpart. By applying a Ca/P coating, the cell proliferation rate on the Ca/P-coated scaffold was significantly improved. The results suggest that high-strength porous TiNbZr scaffolds with an appropriate osteoconductive coating could be potentially used for bone tissue engineering application.

History

Journal

Tissue engineering : part A

Volume

16

Pagination

309-316

Location

New Rochelle, N.Y.

Open access

  • Yes

ISSN

1937-3341

eISSN

1937-335X

Language

eng

Notes

Online Publication Date: September 28, 2009

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2010, Mary Ann Liebert Publishers

Issue

1

Publisher

Mary Ann Liebert Publishers